The Mississippi Highway Patrol said the incident took place on Interstate 20 near Bovina in Warren County.
Seven people, including a 6-year-old boy and his 16-year-old sister, were killed when a bus overturned east of Vicksburg, Mississippi, Warren County Coroner Doug Huskey said.
They were identified by their mother. Authorities are working to identify the other victims, Huskey said.
The Mississippi Highway Patrol said the incident took place early Saturday on Interstate 20 near Bovina in Warren County, when a 2018 Volvo commercial passenger bus traveling westbound left the roadway and overturned.
Thirty-seven passengers were taken to different hospitals with unknown injuries, the agency said. It added that the co-pilot was not transported.
“Anytime there are people injured or killed, it's tragic, but when there's a situation like this, where there are multiple fatalities and multiple injuries, it's even worse,” Warren County Sheriff Martin Pace told an ABC affiliate.
Huskey said most of the bus passengers were Latin American.
The department is continuing its investigation and has not released the names of the deceased. No other information was immediately available.