Northern Illinois kicker Kanon Woodill's 35-yard field goal in the final minute proved to be the difference in the Huskies' matchup with the fifth-ranked Notre Dame Fighting Irish.
Notre Dame attempted a last-second comeback, but a 62-yard field goal was of no use. Northern Illinois would celebrate an improbable 16-14 victory in South Bend, Indiana.
The upset marked the Huskies' first non-conference win against a ranked opponent since a 19-16 victory over the then-21st Alabama Crimson Tide in 2003. It also gave Northern Illinois its first win in program history against a team ranked in the top 10 of the AP Top 25.
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Notre Dame, which had just posted an impressive road win over Texas A&M, looked poised to pull away from Northern Illinois as it clung to a 14-13 lead in the fourth quarter. The Fighting Irish gained possession after a punt with 7:49 left and advanced from their own 25-yard line to the Northern Illinois 49-yard line.
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Irish quarterback Riley Leonard threw a deep pass over the middle intended for Kris Mitchell, but Amariyun Knighten made the interception and returned it 33 yards to the 50-yard line with 5:55 left.
Knighten's interception set up Woodill's game-winning field goal, his third of the day.
Notre Dame struck first when quarterback Riley Leonard eluded the Huskies defense for an 11-yard touchdown run with 8:28 remaining in the first quarter.
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Notre Dame is likely to drop considerably in the standings next week before traveling to West Lafayette for a game against Purdue on Sept. 14. Meanwhile, Northern Illinois will enjoy a bye week before hosting Buffalo on Sept. 21.
The Associated Press contributed to this report.
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