Seven US soldiers were wounded; the Iraqi military says the airstrikes killed key members of the group.
The US military says 15 ISIS fighters have been killed in a joint raid with Iraqi security forces in western Iraq.
Seven US soldiers were wounded in the combined operation that took place on Thursday, the US Central Command (CENTCOM) said in a statement on Saturday.
The raid came as the United States and Iraq were negotiating over their joint security mission in the country.
The fighters were “armed with numerous weapons, grenades and ‘suicide’ explosive belts,” CENTCOM said in X.
No civilian casualties were reported.
Five U.S. soldiers were wounded in the operation, while two others suffered injuries from falls, a U.S. military official told The Associated Press. “All personnel are in stable condition,” he added.
“ISIS remains a threat to the region, our allies, and our homeland,” CENTCOM said, adding that the United States “will continue to aggressively pursue these terrorists” alongside its coalition and Iraqi partners.
The Iraqi military said “the airstrikes targeted the hideouts, followed by an airborne operation.”
“Among the dead there were clues [ISIL] “All hideouts, weapons and logistical support were destroyed, explosive belts were safely detonated and important documents, identification papers and communication devices were confiscated,” he added.
The end date of the US-led coalition's mission, stationed in both Iraq and Syria as a presence against ISIS, was recently postponed.
According to the Reuters news agency, talks on the issue may not be concluded until after the US presidential election in November.
Iraq hosts some 2,500 US troops and also has Iran-aligned militias linked to its security forces.
There are about 900 US troops in Syria as part of the coalition against ISIL.
Coalition forces have been attacked dozens of times by drones and rockets in both Iraq and Syria, while violence related to Israel's war in Gaza, which erupted in October 2023, has involved armed groups linked to Iran across the Middle East.
Earlier this month, at least five US servicemen were wounded in an attack on a military base in Iraq.
Between October and February, an umbrella group of Iran-aligned groups called the Islamic Resistance in Iraq launched regular drone attacks on bases hosting US troops in Iraq and Syria.
At its peak in 2014, IS fighters controlled a third of Iraq and Syria.
A US-led coalition of more than 80 countries forced the group out of Iraq in 2017 and Syria in 2019.
But some fighters remain in hiding, mostly in remote areas, from where they continue to carry out attacks, while also claiming attacks carried out by others in other parts of the world inspired by the group.