Thursday's interview with host Dana Bash will be the first since Harris replaced U.S. President Joe Biden as the Democratic nominee.
Kamala Harris and her running mate Tim Walz will sit down with CNN on Thursday for their first formal interview of the US election campaign.
Harris replaced President Joe Biden as the Democratic nominee for the White House after he dropped out of the race in July.
CNN anchor and chief political correspondent Dana Bash will conduct the interview from the battleground state of Georgia, CNN reported. It will air at 9:00 p.m. (01:00 GMT Friday).
“This is the first time she’s going to be answering questions in a concerted effort like this, in an interview format, since Joe Biden completely changed this race six weeks ago,” CNN political director David Chalian said in an interview on the channel.
While Harris has occasionally answered questions from reporters about foreign and economic policies during the election campaign, she has yet to give a one-on-one interview to the media or hold a formal news conference, prompting attacks from rival Donald Trump and his Republican Party.
On Tuesday, the Trump campaign responded to the interview announcement by saying Harris would do the interview with Walz.
“She is not competent enough to do it alone,” the campaign said.
Trump has held news conferences and given media interviews in recent weeks, but most of them have focused on criticizing the Biden administration’s record rather than detailing his own policy proposals.
Harris laid out some broad policy agendas at the Democratic National Convention last week, promising middle-class tax cuts at home and a forceful foreign policy to confront Russia and North Korea, while backing a ceasefire in Gaza and a two-state solution in the Middle East.
During her more than three years as vice president, Harris has given on-camera and print interviews to The Associated Press and numerous other outlets, often at a more frequent rate than Biden.
Harris travels with members of the media on Air Force Two on every trip and almost always walks to the back of the plane to speak with reporters for a few minutes before takeoff. Her office insists, however, that those conversations are off the record, so what she says cannot be shared publicly.
The CNN interview will be recorded during a campaign bus tour by Democratic candidates.
